The Michael Smith Laboratories at the University of British Columbia in Vancouver invites applications for a Research Associate (RA) position in Evolutionary Biochemistry to join the laboratory of Dr. Nobuhiko Tokuriki. The successful candidate will use high-throughput mutational scanning called deep mutational scanning (DMS) of N-terminus domain (NTD) of the spike protein of coronavirus.

The successful candidate is expected to have completed their PhD and at least four years of postdoctoral research experience. The successful candidate must have advanced capability and research experience in both evolutionary biochemistry, deep mutational scanning and protein chemistry. Specially, the candidate must have demonstrated experience with (1) high-throughput protein characterization platform including yeast display; (2) directed evolution of proteins; (3) generate various mutagenized libraries including libraries contain insertions and deletions; (4) ability to develop and utilize Python script for DMS data analysis; (5) protein purification and biophysical characterizations. Additionally, experience in protein crystallography is preferred. Demonstrated experience must be documented with first-author publications in impact-factor (>5) journals.

The successful candidate must have demonstrated experience in the preparation of research proposals for funding agencies and patent applications. 

Responsibilities will include: Conduct the research project including design, perform and analyze DMS experiments of the NTD domain of coronaviruses and write manuscripts for the publication. Supervise undergraduate students to perform various experiments, molecular cloning, protein purification etc. Supervise the lab organizations including waste disposals, biological and chemical safeties, etc.

The appointment will be initially for one year commencing January 1, 2023 with salary commensurate with qualifications and experience, extendable depending on funding availability.

This posting is for the UBC Vancouver campus in British Columbia, Canada.

Please refer to reference number NC-56433 during correspondence about this position.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

About UBC
The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. Since 1915, UBC’s entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world.

About UBC’s Faculty of Science
UBC Science brings together a community of scholars internationally recognized for its commitment to discovery and innovation—in the lab and in the classroom. Our faculty conduct top-tier research in the life, physical, earth and computational sciences, driving insights into sustainability, biodiversity, human health, nanoscience, new materials, probability, artificial intelligence, exoplanets and more. Ranked among the world’s top 40 universities, UBC’s research prowess in environmental science, math, physics, plant and animal science, computer science, geology, oceanography and biology is consistently rated best in Canada by international and national rankings.

About Vancouver
Vancouver is a dynamic, cosmopolitan and progressive city, consistently ranked as one of the top cities to live in the world. Canada’s third largest city has it all: sea, parks, mountains, beaches, and four seasons per year, including beautiful summers and mild, wet winters with snow in the mountains. It’s the perfect backdrop to your academic research.

How to apply:

Applicants should send, no later than August 20, 2022, their curriculum vitae, list of publications and the names of three referees to Dr. Nobuhiko Tokuriki (

Apply now

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