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Applications are invited for postdoctoral research associate in molecular genetics, working with David Baulcombe and his group in the Department of Plant Sciences, University of Cambridge. The positions are BBSRC funded for 12 months, starting as soon as possible. Analysis of the epigenome in tomato.
The BBSRC funded project to extends earlier work on epigenetics and heritable patterns of gene expression in tomato. In recent work, we describe the effects of a cmt3 mutation in tomato that removes a subset of the epigenetic marks in both pericentric and distal regions of the tomato chromosomes.
In the current project we aim to identify genome features that influence the establishment and maintenance of epigenetic marks. What defines the loci that have stable epigenetic marks from those with either unstable marks or that are do not have either DNA methylation or chromatin modifications?
The proposed work will involve extensive and detailed characterization of the epigenome and patterns of gene expression in tomato lines derived from cmt3 mutants using molecular and computational approaches. The analysis will include a multiple correspondence analysis in order to classify the epigenome in terms of struct features or combinations of features that correlate with epigenetic marks
We are looking for a highly motivated individual with a background in genetics and molecular biology. A high level of bioinformatic and statistical skill is essential. The project uses plant virus vectors for expression and silencing and relevant previous experience would be helpful. Familiarity with the general field of epigenetics would be an asset.
The vacancy arises because a current postdoc has an alternative career development opportunity. They have generated exciting preliminary data and there is an opportunity to extend these findings for early publication.
The successful candidate should be capable of working independently on this project, whilst integrated into an interactive and supportive research group. Together with PI David Baulcombe they will supervise a research technician. Fixed-term: The funds for this post are available for 12 months in the first instance.
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Please quote reference PD34939 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.